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Advanced Proteome Therapeutics

Technology

Technology Overview

Proteins are large molecules with important functional roles that represent a growing class of therapeutics. Unmodified proteins generally possess short circulating times that necessitate their frequent administration, often by injection, to achieve therapeutic efficacy. However, certain modifications of proteins that can be appended to their surface have achieved, and hold forth continued promise, of producing superior drugs. A natural protein is not easily modified at specific spots along its large surface by chemical means. The normal course of chemical modification of proteins is to produce mixtures. It is difficult, impractical, and not cost- effective to purify individual components from such mixtures. This situation places a limitation on the ability to augment or improve therapeutic properties of a protein.

This approach affords the opportunity of improving existing suboptimal drugs with established markets and needy patient populations, and avoiding the costly and long research and development times required to create or discover new drugs. In essence our approach is to stitch known efficacy-enhancing entities, to clinically useful sites of a protein target that can be rapidly screened for clinical utility and potential.

 

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