Vancouver, British Columbia / May 28, 2020 – Advanced Proteome Therapeutics Corporation (“APC” or the “Company”) (TSXV: APC) (FSE: 0E8), is pleased to announce that it’s US subsidiary, Advanced Proteome Therapeutics Inc. (“APTI”), has received first results as part of its collaborative pilot project with a promising Boston based biotechnology company (“Biotech”), as announced on February 10, 2020. The pilot project is testing APTI’s site specific conjugation technology with Biotech’s proprietary antibody against a high-value target.
APTIs antibody-drug conjugate (ADC) construct was compared to an ADC construct utilizing the same antibody, toxin and drug to antibody ratio, but alternative conjugation technology. In cell culture studies conducted by Biotech, APTIs ADC demonstrated over 15 times greater potency than the comparator ADC. Based on these results further studies are planned in different models. These further studies are expected to take place upon reopening of the two companies’ laboratories in Boston.
Dr. Benjamin Krantz, Director of APTI commented “This is a fantastic result which shows greater potency of the ADC utilizing APT’s site-specific, homogeneous conjugation technology in this in vitro model. This is particularly exciting because we expect the most significant benefits from APTs ADC conjugation technology to be in vivo, where ADC stability and activity are challenged under physiologic conditions. We look forward to continuing this collaboration and development of this promising ADC.”
Terms of any agreement are to be finalized after pilot completion. The antibody is directed at a highly attractive target that has yet to be successfully addressed. It is overexpressed in up to 90% of malignancies including breast, lung, pancreas, colon and many others. Biotech’s in depth understanding of the target biology has enabled targeting a unique portion that overcomes the limitations of previous strategies. Prior pre-clinical study has demonstrated that both the antibody and target have the appropriate characteristics and therefore substantial promise for ADC therapies. Paul Woodward, CEO of Advanced Proteome Therapeutics Corporation states “This result is another step on the road to proving that APTI’s technology is the gold standard of conjugation technologies, technology that will enable the creation of safer and more efficacious ADC therapeutics for patients.”
ABOUT THE COMPANY:
Advanced Proteome Therapeutics Corporation, through its subsidiary, Advanced Proteome Therapeutics Inc., has invented proprietary protein conjugation technology which enables the development of superior antibody-drug conjugates through improved site-specific labeling, drug-antibody ratio control and enabling of combination payloads. The technology has compelling pre-clinical data demonstrating improved homogeneity and increased in-vivo potency relative to current state of the art linker technology. The Company believes that the technology will enable the development of safer and more potent antibody-drug conjugate therapeutics and is pursuing licensing and partnership opportunities to advance development and create shareholder value.
FOR FURTHER INFORMATION PLEASE CONTACT:
Advanced Proteome Therapeutics Corporation
Paul Woodward
President and CEO
Tel: (604)690-3797
https://www.advancedproteome.com
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